![]() ![]() ![]() Cell viability, LAC concentration, calcium concentration, mitochondrial membrane potential (ΔΨm), MMPs proteins, and apoptotic related proteins were detected. NP cells were treated with different concentrations of pramlintide in normoxic or hypoxic conditions. The goals of this study were to investigate the roles of pramlintide in the regulation of cell survival and matrix metabolism, and further explore their underlying mechanisms, in human nucleus pulposus (NP) cells. Pramlintide, an approved analog of amylin, is responsible for regulating the physiology of energy homeostasis. ![]()
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